Pancreatic Ductal and Acinar Cell Neoplasms in Carney Complex: A Possible New Association
نویسندگان
چکیده
منابع مشابه
Defining Contributions of Pancreatic Ductal and Acinar Cells to Tumorigenesis
The cellular origin of pancreatic tumors remains a vital topic for research to further our understanding of carcinogenesis. We currently do not know if cellular origin determines the phenotype of pancreatic tumors. Ninety percent of newly diagnosed pancreatic cancers are ductal adenocarcinomas (PDA). The majority of PDA are thought to originate from low-grade precursor tumors termed pancreatic ...
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Ductal adenocarcinoma is by far the most frequent tumor of the pancreas. Although pancreatic cancer cells share substantial characteristics with pancreatic duct cells, the origin of these cancer cells is still a matter of debate. Progressive changes in the ductal epithelium range from non-papillary to papillary hyperplasia, with little or no development of atypical or dysplastic epithelial lesi...
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The exocrine pancreas can undergo acinar-to-ductal metaplasia (ADM), as in the case of pancreatitis where precursor lesions of pancreatic ductal adenocarcinoma (PDAC) can arise. The NAD(+)-dependent protein deacetylase Sirtuin-1 (Sirt1) has been implicated in carcinogenesis with dual roles depending on its subcellular localization. In this study, we examined the expression and the role of Sirt1...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2011
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2011-1433